Induction of HIV‐1 Nef‐specific cytotoxic T lymphocytes by Nef‐expressing DNA vaccine
نویسندگان
چکیده
منابع مشابه
Cytotoxic T Lymphocytes and Vaccine Development 2013
CTLs play a critical role in �ghting chronic virus infection and cancers. Despite the tremendous efforts spent so far, generating potent and highly effective CTLs remain a major roadblock for disease control (prevention and therapies). Activation of CTLs requires different stimuli and is in�uenced by different disease conditions. In this special issue, several papers investigated functions of c...
متن کاملCytotoxic T Lymphocytes and Vaccine Development
Along with the development of new technology, the molecular mechanisms of the generation of functional CTLs have been elucidated over the last several years which together will undoubtedly enhance our progression towards the development of successful vaccines for the many chronic viral infections and cancer. It has been shown that the activation of naı̈ve CTLs requires all three signals to be fu...
متن کاملCytotoxic T Lymphocytes and Vaccine Development 2011
Research on CTLs has been booming in recent years—there are more than 250 papers related to CD8 T-cells published everymonth.With such rapid advancement in this particular aspect of immunology alone, it is important to summarize and report information on this hot topic in a timely and organized fashion. Although the submission window for this issue was open for a significantly shorter period co...
متن کاملResistance of cytotoxic T lymphocytes to lysis by a clone of cytotoxic T lymphocytes.
To investigate how cytotoxic T lymphocytes (CTL) avoid killing themselves when they destroy target cells, we compared 20 different cell lines as target cells, including several CTL cell lines, for their susceptibility to lysis by CTL. Variations in recognition of this diverse set of target cells was circumvented by attaching to all of them a monoclonal antibody to the antigen-specific receptor ...
متن کاملRegulation of the Induction and Function of Cytotoxic T Lymphocytes by Natural Killer T Cell
Cytotoxic T lymphocytes (CTLs) play a crucial role in the infections and the antitumor immunity. Induction and activation of antigen-specific CTLs is an important strategy in immunotherapy for various diseases, and several researchers have focused on the modulation of CTL induction and function. Natural killer T (NKT) cells are an important focus area of researchers studying immunomodulatory re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 1996
ISSN: 0361-8609,1096-8652
DOI: 10.1002/(sici)1096-8652(199610)53:2<116::aid-ajh9>3.3.co;2-1